The Daily Wellness Company, the makers of ArginMax, is committed to supporting scientific research. Daily Wellness has taken a methodical and scientific approach toward the development of ArginMax in order to establish the highest level of credibility and consumer trust.

Clinical studies were conducted on the effectiveness of ArginMax. The results of these studies were published in the following journals:

"The Enhancement of Female Sexual Function with ArginMax, a Nutritional Supplement, Among Women Differing in Menopausal Status". Journal of Sex & Martial Therapy. 2006. Volume 32. Page 369-378.
To see the study, click here.

"Clinical Study of ArginMax, A Nutritional Supplement for the Enhancement of Female Sexual Function". Journal of Women's Health and Gender-Based Medicine . May 2001. Volume 10, Number 4.
To see the study, click here.

Preliminary results from a study on ArginMax for Women were presented at the international symposium entitled "New Perspectives In The Management of Female Sexual Dysfunction" held at Boston University on October 23, 1999. This meeting was attended and conducted by the world's leading experts on female sexual function.  The final results were recently published in October-December 2001 issue of the peer-reviewed Journal of Sex and Marital Therapy. To view the study, click here. The following is a summary of the study's final results.

A Double-Blind Placebo-Controlled Study on ArginMax, a Nutritional Supplement for Enhancement of Female Sexual Function

Anurag K. Das MD FACS¹, Thomas Y. Ito MD², Aileen S. Trant PhD³,
Mary Lake Polan MD PhD⁴

1 Associate Professor of Urology, Albany Medical College
² Assistant Professor of Urology, Univ. of Hawaii School of Medicine
³ The Daily Wellness Company
⁴ Professor and Chair, Dept. of Gyn-Ob, Stanford Univ. School of Medicine

Correspondence: Mary Lake Polan, MD, PhD. Professor & Chair, Dept of Gyn/Ob, Stanford Univ. School of Medicine, 300 Pasteur Dr., Stanford, CA, 94305.

INTRODUCTION
This pilot study explores the role of nutritional supplementation in female sexual function. The scientific literature indicates that certain botanical extracts, vitamins, or amino acids may play a role in sexual function, including:

L-Arginine
· Precursor to nitric oxide (NO).
· NO may modulate vaginal blood supply and smooth muscle relaxation.
· Supplementation impacts NO production.
· May reduce cell-mediated breakdown of cGMP.

Korean Ginseng (Panax Ginseng):
· Ginsenosides may up-regulate NOS activity, hence enhance the conversion of L-Arginine to NO.
· Ginsenosides shown to increase NO production in endothelial cells.

Ginkgo Biloba:
· Facilitates microvascular circulation.

Damiana:
· Helps promote a relaxed state of mind.
· Phyto-progestin receptor binding activity.

ArginMax (www.arginmax.com, The Daily Wellness Company), is a daily nutritional supplement consisting of highly standardized:
· L-arginine
· Korean ginseng (Panax Ginseng-30% ginsenosides)
· Ginkgo biloba (24% flavone glycosides, 6% terpene lactones)
· Damiana (Turnera Aphrodisiaca)
· 14 vitamins and minerals including vitamins A,C,E, B6, B12, folate, thiamin, riboflavin, niacin, biotin, pantothenic acid, zinc, calcium, and iron.

This study examines a systematically designed combinatorial nutritional supplement for the enhancement of female sexual function using the Female Sexual Function Index (FSFI), a validated assessment instrument.

METHODS
· 77 women with sexual dysfunction
· Enrolled consecutively
· Two groups randomly assigned active or placebo in a double blind fashion
· Baseline & 4 weeks medical history, physical examination, BP measurement, and assessment using FSFI
· Daily regimen of ArginMax for 4 weeks

RESULTS (Based on FSFI assessment):

• 70.6% improved in sexual desire level
  (placebo=41.9%), (p<0.01)
• 73.5% improved in satisfaction with sex life
  (placebo=37.2%), (p<0.01)
• 61.8%  improved in sexual relationship with partner
  (placebo=34.9%), (p<0.01)
• 47.1% improved in frequency of orgasms
  (placebo=30.2%), (p<0.07)
• 52.9% improved in clitoral sensation to stimulation
  (placebo=34.9%), (p<0.06)

	ArginMax	Placebo
Total # of subjects	34	43
Age range, mean	24-71, 44.5	22-68, 41.0

 

DISCUSSION
Our study evaluated the role of nutritional supplementation in female sexual health. Proposed mechanism is through up-regulation of the nitric oxide (NO) pathway resulting in smooth muscle relaxation, vascular dilatation, and enhancement of peripheral circulation, resulting in improved clitoral engorgement and vaginal lubrication.

Role of nutritional supplements for sexual health is an infrequently discussed yet extremely important subject which warrants in-depth research.

CONCLUSION
Based on the findings of this study, there appears to be a clinically important role for nutritional supplementation in sexual health and female sexual function. The expansion of the current study protocol is expected to exceed several hundred patients.